Holistic 3D modeling of molecularly defined brain structures is crucial for understanding complex brain functions. Emerging tissue profiling technologies enable the construction of a comprehensive atlas of the mammalian brain with sub-cellular resolution and spatially resolved gene expression data. However, such tera-scale volumetric datasets present significant computational challenges in understanding complex brain functions within their native 3D spatial context. Here, we propose the novel generative approach $\textbf{Tera-MIND}$, which can simulate $\textbf{Tera}$-scale $\textbf{M}$ouse bra$\textbf{IN}$s in 3D using a patch-based and boundary-aware $\textbf{D}$iffusion model. Taking spatial transcriptomic data as the conditional input, we generate virtual mouse brains with comprehensive cellular morphological detail at teravoxel scale. Through the lens of 3D $gene$-$gene$ self-attention, we identify spatial molecular interactions for key transcriptomic pathways in the murine brain, exemplified by glutamatergic and dopaminergic neuronal systems. Importantly, these $in$-$silico$ biological findings are consistent and reproducible across three tera-scale virtual mouse brains. Therefore, Tera-MIND showcases a promising path toward efficient and generative simulations of whole organ systems for biomedical research. Project website: https://musikisomorphie.github.io/Tera-MIND.html

Current orthopedic robotic systems largely focus on navigation, aiding surgeons in positioning a guiding tube but still requiring manual drilling and screw placement. The automation of this task not only demands high precision and safety due to the intricate physical interactions between the surgical tool and bone but also poses significant risks when executed without adequate human oversight. As it involves continuous physical interaction, the robot should collaborate with the surgeon, understand the human intent, and always include the surgeon in the loop. To achieve this, this paper proposes a new cognitive human-robot collaboration framework, including the intuitive AR-haptic human-robot interface, the visual-attention-based surgeon model, and the shared interaction control scheme for the robot. User studies on a robotic platform for orthopedic surgery are presented to illustrate the performance of the proposed method. The results demonstrate that the proposed human-robot collaboration framework outperforms full robot and full human control in terms of safety and ergonomics.

Routine inspections for critical infrastructures such as bridges are required in most jurisdictions worldwide. Such routine inspections are largely visual in nature, which are qualitative, subjective, and not repeatable. Although robotic infrastructure inspections address such limitations, they cannot replace the superior ability of experts to make decisions in complex situations, thus making human-robot interaction systems a promising technology. This study presents a novel gaze-based human-robot interaction system, designed to augment the visual inspection performance through mixed reality. Through holograms from a mixed reality device, gaze can be utilized effectively to estimate the properties of the defect in real-time. Additionally, inspectors can monitor the inspection progress online, which enhances the speed of the entire inspection process. Limited controlled experiments demonstrate its effectiveness across various users and defect types. To our knowledge, this is the first demonstration of the real-time application of eye gaze in civil infrastructure inspections.

This paper investigates resource allocation to provide heterogeneous users with customized virtual reality (VR) services in a mobile edge computing (MEC) system. We first introduce a quality of experience (QoE) metric to measure user experience, which considers the MEC system's latency, user attention levels, and preferred resolutions. Then, a QoE maximization problem is formulated for resource allocation to ensure the highest possible user experience,which is cast as a reinforcement learning problem, aiming to learn a generalized policy applicable across diverse user environments for all MEC servers. To learn the generalized policy, we propose a framework that employs federated learning (FL) and prompt-based sequence modeling to pre-train a common decision model across MEC servers, which is named FedPromptDT. Using FL solves the problem of insufficient local MEC data while protecting user privacy during offline training. The design of prompts integrating user-environment cues and user-preferred allocation improves the model's adaptability to various user environments during online execution.

Recently, the scientific progress of Advanced Driver Assistance System solutions (ADAS) has played a key role in enhancing the overall safety of driving. ADAS technology enables active control of vehicles to prevent potentially risky situations. An important aspect that researchers have focused on is the analysis of the driver attention level, as recent reports confirmed a rising number of accidents caused by drowsiness or lack of attentiveness. To address this issue, various studies have suggested monitoring the driver physiological state, as there exists a well-established connection between the Autonomic Nervous System (ANS) and the level of attention. For our study, we designed an innovative bio-sensor comprising near-infrared LED emitters and photo-detectors, specifically a Silicon PhotoMultiplier device. This allowed us to assess the driver physiological status by analyzing the associated PhotoPlethysmography (PPG) signal.Furthermore, we developed an embedded time-domain hyper-filtering technique in conjunction with a 1D Temporal Convolutional architecture that embdes a progressive dilation setup. This integrated system enables near real-time classification of driver drowsiness, yielding remarkable accuracy levels of approximately 96%.

Visual Saliency refers to the innate human mechanism of focusing on and extracting important features from the observed environment. Recently, there has been a notable surge of interest in the field of automotive research regarding the estimation of visual saliency. While operating a vehicle, drivers naturally direct their attention towards specific objects, employing brain-driven saliency mechanisms that prioritize certain elements over others. In this investigation, we present an intelligent system that combines a drowsiness detection system for drivers with a scene comprehension pipeline based on saliency. To achieve this, we have implemented a specialized 3D deep network for semantic segmentation, which has been pretrained and tailored for processing the frames captured by an automotive-grade external camera. The proposed pipeline was hosted on an embedded platform utilizing the STA1295 core, featuring ARM A7 dual-cores, and embeds an hardware accelerator. Additionally, we employ an innovative biosensor embedded on the car steering wheel to monitor the driver drowsiness, gathering the PhotoPlethysmoGraphy (PPG) signal of the driver. A dedicated 1D temporal deep convolutional network has been devised to classify the collected PPG time-series, enabling us to assess the driver level of attentiveness. Ultimately, we compare the determined attention level of the driver with the corresponding saliency-based scene classification to evaluate the overall safety level. The efficacy of the proposed pipeline has been validated through extensive experimental results.

This work presents a new multimodal system for remote attention level estimation based on multimodal face analysis. Our multimodal approach uses different parameters and signals obtained from the behavior and physiological processes that have been related to modeling cognitive load such as faces gestures (e.g., blink rate, facial actions units) and user actions (e.g., head pose, distance to the camera). The multimodal system uses the following modules based on Convolutional Neural Networks (CNNs): Eye blink detection, head pose estimation, facial landmark detection, and facial expression features. First, we individually evaluate the proposed modules in the task of estimating the student's attention level captured during online e-learning sessions. For that we trained binary classifiers (high or low attention) based on Support Vector Machines (SVM) for each module. Secondly, we find out to what extent multimodal score level fusion improves the attention level estimation. The mEBAL database is used in the experimental framework, a public multi-modal database for attention level estimation obtained in an e-learning environment that contains data from 38 users while conducting several e-learning tasks of variable difficulty (creating changes in student cognitive loads).

This paper describes a system developed to help University students get more from their online lectures, tutorials, laboratory and other live sessions. We do this by logging their attention levels on their laptops during live Zoom sessions and providing them with personalised video summaries of those live sessions. Using facial attention analysis software we create personalised video summaries composed of just the parts where a student's attention was below some threshold. We can also factor in other criteria into video summary generation such as parts where the student was not paying attention while others in the class were, and parts of the video that other students have replayed extensively which a given student has not. Attention and usage based video summaries of live classes are a form of personalised content, they are educational video segments recommended to highlight important parts of live sessions, useful in both topic understanding and in exam preparation. The system also allows a Professor to review the aggregated attention levels of those in a class who attended a live session and logged their attention levels. This allows her to see which parts of the live activity students were paying most, and least, attention to. The Help-Me-Watch system is deployed and in use at our University in a way that protects student's personal data, operating in a GDPR-compliant way.

"Nothing was your own except the few cubic centimeters inside your skull." That's from George Orwell's dystopian novel 1984, published in 1949. The comment is meant to highlight what a repressive surveillance state the characters live in, but looked at another way, it shows how lucky they are: At least their brains are still private. Over the past few weeks, Facebook and Elon Musk's Neuralink have announced that they're building tech to read your mind -- literally. Mark Zuckerberg's company is funding research on brain-computer interfaces (BCIs) that can pick up thoughts directly from your neurons and translate them into words.

This paper presents a semantic brain computer interface (BCI) agent with particle swarm optimization (PSO) based on a Fuzzy Markup Language (FML) for Go learning and prediction applications. Additionally, we also establish an Open Go Darkforest (OGD) cloud platform with Facebook AI research (FAIR) open source Darkforest and ELF OpenGo AI bots. The Japanese robot Palro will simultaneously predict the move advantage in the board game Go to the Go players for reference or learning. The proposed semantic BCI agent operates efficiently by the human-based BCI data from their brain waves and machine-based game data from the prediction of the OGD cloud platform for optimizing the parameters between humans and machines. Experimental results show that the proposed human and smart machine co-learning mechanism performs favorably. We hope to provide students with a better online learning environment, combining different kinds of handheld devices, robots, or computer equipment, to achieve a desired and intellectual learning goal in the future.